Best-rated hotels in Panacea for your unforgettable stay

Detailed descriptions, travelers’ reviews, and handpicked hotel collections will help you book your perfect accommodation.

Check-in date:
Check-out date:
0 Adults

Adults

0 Children

Children

Apply

Why book with us?

Choose from exclusive hotel collection

We offer thousands of Panacea hotels and accommodations from world's renowned hotel chains to unique gems of the region you won’t find anywhere else.

Enjoy seamless booking experience

Once you choose your best place to stay, take a minute to complete a quick reservation form and get an instant confirmation letter to your email address.

Benefit from flexible travel options

We provide the most flexible cancellation options, so you get your deposit back in case of a change of plans or other unforeseen circumstances.

Find a hotel

Hotels by class
5 stars 1
Unrated 19
Accommodation type
Holiday homes 18
Hotel 1
Apartment 1
Thematic Hotels
Extended Stay 19
Vacation Rentals 19
Luxury accommodations 10
Pet-friendly hotels 8
Private Villas 8
Family Friendly hotels 6
Beachfront hotels 5
Beach hotels 5
Cheap and budget hotels 4
Jacuzzi 1
Luxury hotels 1
Hotels with indoor pool 1
All Panacea hotels

Hotels by location

Nearby
City Center Panacea 1
Landmarks
Popular attractions
Florida >
Panacea

Welcome to Panacea

Step into a place where paradise meets serenity, Panacea awaits. Discover breathtaking beaches, crystal-clear waters, and vibrant coral reefs teeming with marine life. Unwind amidst lush rainforests, embark on awe-inspiring hikes, and indulge in mouthwatering delicacies. Experience the magic of Panacea and create unforgettable memories. Immerse yourself in this tropical haven and let your wanderlust guide you to its wonders!

What our users say about Panacea hotels

Floridays Orlando Two & Three Bed Rooms Condo Resort
9.8

Exceptional

us Sarah 14 January 2023
The accommodation is pet-friendly, well-equipped with spacious private bathrooms, and provides efficient service, even though some staff members may not be very helpful.
Read more +
Show Less -
The Grove Resort & Water Park Orlando
9.8

Exceptional

us Peter 07 June 2022
The hotel was hip new, had stunningly beautiful views and perfect location close to a water park and near by attractions and the center. I appreciated the room, the bed was comfy. There were a flat-screen TV with cable channels, climate control and a refrigerator. The staff was excellent, they made the stay good.
Read more +
Show Less -
Holiday Inn Resort Orlando Suites - Waterpark By Ihg
9.8

Exceptional

us Willie 27 December 2022
Thanks very much all for an awesome stay during our visit.
Read more +
Show Less -
Best Western Orlando Gateway Hotel
9.8

Exceptional

us John 13 December 2022
The rooms and the staff here are top-notch. We were impressed by almost every little thing at this place! 😊
Read more +
Show Less -
Sandestin Golf And Beach Resort
9.8

Exceptional

us Brian 14 November 2022
The great location within walking distance of Alvin's Island and the luxurious room with extremely comfortable beds make this place a top choice for a relaxing stay.
Read more +
Show Less -
Buena Vista Suites Orlando
9.8

Exceptional

us Ian 14 September 2022
The rooms were clean and had a fantastic bathroom, located in a beautiful building in a convenient area close to the Bistro.
Read more +
Show Less -
Caribe Royale Orlando
9.8

Exceptional

us William 13 October 2022
I had a wonderful family vacation here, the staff was great, the rooms were nice, and the bed was super comfortable.
Read more +
Show Less -
DoubleTree by Hilton Hotel Orlando at SeaWorld
9.8

Exceptional

us Gregory 24 January 2022
Everything was perfect here - helpful staff and non-smoking rooms.
Read more +
Show Less -
Doubletree By Hilton At The Entrance To Universal Orlando
9.8

Exceptional

us Lisa 14 September 2022
The location was amazing, very close to Universal Studios, liquor stores, parks, restaurants. It was not too far from Trattoria del Porto; we ate there a couple of times.
Read more +
Show Less -
B Ocean Resort Fort Lauderdale Beach
9.8

Exceptional

us Paul 13 January 2023
Decent spot, quite tidy and cool. Liked it. Room was pretty clean and had a good view. 🌅
Read more +
Show Less -

Save time on your trip arrangements by booking one of our hand-picked hotels

Top 5-star hotels
Indulge yourself with luxury and comfort as you explore the exciting attractions of Panacea.
The Panacea Motel

1545 Coastal Highway, Panacea, United States

Good
71 reviews

131 US$

min. price/night

Travelers’ choice

Check out the most booked accommodations to find reliable places that our users have tried and tested.
Romantic Getaway Bayside

19 Mashes Sands Road, Panacea, United States

Excellent
24 reviews

206 US$

min. price/night

Waterfront Ochlockonee Bay Cottage With Views!

42 Joe Dr, Panacea, United States

Excellent
6 reviews

298 US$

min. price/night

Waterfront Home Spectacular On-Site Fishing!

15 Shoreline Dr, Panacea, United States

Excellent
3 reviews

294 US$

min. price/night

Waterfront Escape With Balcony On Shell Point Beach!

179 Beaty Taff Drive, Crawfordville, FL 32327, US, Panacea, United States

Excellent
3 reviews

318 US$

min. price/night

Show less Show more

Thank you for your feedback

Close